![]() Raynaud’s phenomenon, also referred to as Raynaud’s disease, is an autoimmune condition sometimes associated with Sjögren’s. Painless, swollen lymph nodes are often the first sign of lymphoma. People often have small, soft lumps that may be tender or painful to the touch. Lymphadenopathy is a condition in which the lymph nodes swell or enlarge and can occur in people with Sjögren’s. However, it can also occur in the salivary glands located under the tongue and the jaw. This swelling most often occurs in the parotid glands, which are found behind the jaw near the ears. According to one study, people with Sjögren’s syndrome with lymphoma most often developed cancer in their salivary glands.Įnlarged salivary glands can be painful and may make it difficult to move the jaw while talking or eating. Some people diagnosed with Sjögren’s find that their salivary glands swell significantly. People with all seven risk factors have nearly a 100 percent chance of being diagnosed with lymphoma at some point.Those with three to six risk factors have a 39.9 percent chance of developing lymphoma.People with two or fewer of these signs and symptoms have a 3.8 percent chance of developing the condition.Researchers have determined the risks as follows: Having any one of the following risk factors alone does not necessarily mean that you have a higher risk of developing lymphoma. ![]() Many of these factors can be identified using blood testing. ![]() They have found that certain factors - including swollen salivary glands and Raynaud’s phenomenon - seem to predispose a person with Sjögren’s to develop NHL as well. Researchers are not yet sure how Sjögren’s syndrome and NHL are connected. Which Signs and Symptoms of Sjögren’s Syndrome Predict the Development of Lymphoma? An earlier study supported this conclusion, as it indicated that some people in the study developed lymphoma before they were diagnosed with Sjögren’s syndrome.īecause this study is so recent, more research is necessary to determine how Sjögren’s syndrome and NHL are connected. The risk of developing one condition after being diagnosed with the other appears to be the highest in the initial year after the first diagnosis. In early 2020, researchers found that having a diagnosis of non-Hodgkin lymphoma may also predispose a person to develop Sjögren’s syndrome. Swollen (but painless) glands, often in the neck, armpit, or groin areas.If you have Sjögren’s syndrome, you may have: This is important, as NHL is often curable when found early. They will explain the symptoms of NHL and ask you to keep an eye out for them. If you are diagnosed with Sjögren’s syndrome, your doctor will most likely tell you about the potential risk of developing NHL. Despite this connection, the chances of developing NHL with Sjögren’s syndrome are still minimal. Research has found that people diagnosed with Sjögren’s syndrome are approximately five times more likely than those in the general population to develop non-Hodgkin lymphoma (NHL) - cancer that originates in the lymphocytes (a type of white blood cell). The Connection Between Sjögren’s Syndrome and Lymphoma ![]() It can occur by itself (which is called primary Sjögren’s syndrome) or alongside other autoimmune conditions. Sjögren’s syndrome is usually diagnosed in women over the age of 40, many of whom have also been diagnosed with rheumatic diseases such as rheumatoid arthritis or lupus. However, it also appears that there must be a specific trigger - such as infection with certain viruses or bacteria - before the syndrome develops. There seems to be a genetic predisposition, as those with certain genes seem more likely to develop the condition. No one knows exactly what causes or triggers Sjögren’s syndrome. However, Sjögren’s syndrome can also target other areas of the body, potentially causing vaginal dryness, swollen salivary glands, dry skin, muscle and/or joint pain, and exhaustion. The characteristic symptoms of Sjögren’s syndrome are dry mouth and dry eyes. It most commonly targets the parts of the body responsible for producing fluids, such as saliva and tears. It occurs when the immune system mistakenly attacks the body’s healthy tissues. Sjögren’s syndrome is an autoimmune disease.
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